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Your Vote Counts! MERSANA THERAPEUTICS, INC. 840 MEMORIAL DRIVE CAMBRIDGE, MA 02139 MERSANA THERAPEUTICS, INC. 2022 Annual Meeting to be held June 9, 2022 at 9 AM ET Vote by June 8, 2022 11:59 PM ET You invested in MERSANA THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 9, 2022. Vote Virtually at the Meeting* Vote on June 9, 2022 9:00 AM ET Visit www.virtualshareholdermeeting.com/MRSN2022 Vote in Advance of the Meeting Vote by June 8, 2022 11:59 PM ET Visit www.ProxyVote.com *Please check the meeting materials for any special requirements for meeting attendance. Smartphone users Point your camera here and vote without entering a control number V1.1 To view the proxy materials and to vote, visit www.ProxyVote.com Control # D81963-P71991 Get informed before you vote View the Notice of Annual Meeting and Proxy Statement and Annual Report online at www.ProxyVote.com OR you can receive a free paper or email copy of the material(s) by requesting prior to May 26, 2022. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy.


THIS IS NOT A VOTABLE BALLOT This is an overview of the more complete proxy materials that are available to you on the Internet. We encourage you to access and review all of the important information contained in the proxy materials before voting. Please follow the instructions on the reverse side to vote these important matters. Vote at www.ProxyVote.com Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. Voting Items Board Recommends D81964-P71991 1. Election of Class II Directors, each to serve until the 2025 Annual Meeting of Stockholders Nominees: 1c. Kristen Hege, M.D. 1a. Allene M. Diaz 2. To ratify the selection of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2022. 1b. Andrew A. F. Hack, M.D., Ph.D. 3. To approve, on a non-binding, advisory basis, the compensation of the Company’s named executive officers. 4. To approve an amendment to the Company’s Fifth Amended and Restated Certificate of Incorporation to increase the number of authorized shares of common stock from 175,000,000 shares to 350,000,000 shares. NOTE: Such other business as may properly come before the meeting or any adjournment thereof. For For For For For For