Mersana Therapeutics Presents New Preclinical Data from Immunosynthen Platform at the Society for Immunotherapy of Cancer (SITC) 34th Annual Meeting
The poster describes the results of studies in which Mersana utilized its expertise to generate novel ADCs providing targeted delivery of a STimulator of Interferon Genes (STING) agonist and investigated their activity and mechanism of action in vitro and in vivo. STING has emerged as an innate immune pathway capable of inducing anti-tumor immune activity.
“We are excited by these preclinical data which demonstrate that STING ADCs activate a local immune response leading to tumor regression while limiting systemic toxicities,” said
The data show that STING ADCs achieved greater than 100-fold higher potency than the corresponding free agonist in in vitro assays. Similarly, in tumor cell/PBMC co-cultures the targeted STING ADC induced greater than 100-fold higher potency of tumor cell-killing by PBMCs compared to free agonist, demonstrating the benefits of the platform. In vivo data show potent antitumor activity, with a single administration of the targeted STING ADC inducing sustained tumor regressions. At the dose level that regressed tumors, the targeted STING ADCs showed significantly lower induction of serum cytokines relative to a systemically administered STING agonist despite maintaining extended plasma exposure.
“The opportunity to harness the innate immune system to attack tumors represents the next frontier in immuno-oncology,” said Anna Protopapas, President and CEO of
Details of the presentation are as follows:
Poster Title: “Tumor Targeting of a STING Agonist with an Antibody-Drug Conjugate Elicits Potent Anti-Tumor Immune Responses”
Category: Immuno-conjugates and chimeric molecules
Poster: # P695
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Source: Mersana Therapeutics, Inc.